Peer-reviewed science.
Clinical-grade sequencing.
Every AuraGen report is built on published GWAS findings, CPIC-guideline pharmacogenomics, and clinical-depth sequencing — not consumer SNP arrays. Here is how the science works.
The science behind every report.
Polygenic Risk Scores
Most disease risk isn't determined by a single gene — it's the cumulative effect of thousands of common variants, each contributing a small amount. A polygenic risk score (PRS) sums these contributions using odds ratios from genome-wide association studies (GWAS), then places your score on a population percentile curve.
AuraGen PRS models use the weighted sum method — the international standard used by UK Biobank, PGS Catalog, and all major GWAS consortia. Effect sizes come from the largest published meta-analyses (CARDIoGRAMplusC4D, BCAC, Mavaddat et al.). Population calibration uses UK Biobank n=337,000+.
Pharmacogenomics
Drug response is highly heritable. Variants in CYP2D6, CYP2C19, SLCO1B1, DPYD, and dozens of other genes determine whether a medication reaches therapeutic levels, builds to toxic concentrations, or fails to activate at all. AuraGen PGx follows CPIC Level A guidelines — the highest evidence tier in clinical pharmacogenomics.
Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines are developed by international expert panels and represent the strongest available evidence for genotype-guided prescribing. CPIC Level A means there is sufficient evidence to recommend changing prescribing based on genotype.
Whole Exome & Whole Genome
SNP arrays test ~700,000 fixed positions. Whole exome sequencing (WES) reads every protein-coding base — ~50 million bases, revealing rare variants no array would catch. Whole genome sequencing (WGS) goes further, capturing regulatory regions, structural variants, and the full non-coding genome.
AuraGen uses 100× mean exome depth (WES) and 30× whole genome depth (WGS) — clinical-grade coverage thresholds. Alignment via BWA-MEM2, variant calling via GATK HaplotypeCaller, annotation via ClinVar, gnomAD, and OMIM. Raw FASTQ delivered with every WGS kit.
Population Genetics & Ancestry
A variant with OR=1.25 in one population may have a different frequency — and therefore a different population-level impact — in another. AuraGen reports your ancestry composition and applies ancestry-appropriate population parameters where available. We are transparent about where multi-ancestry models are still in development.
Principal component analysis (PCA) against 1000 Genomes Project super-populations. gnomAD allele frequencies stratified by ancestry. We actively monitor the PGS Catalog for updated multi-ancestry models and update AuraGen Refresh subscribers annually as new models are validated.
See PRS in action.
Change genotypes. Watch it move.
Our interactive calculator uses the exact same GWAS effect sizes and population statistics that power real AuraGen reports — across 6 disease panels, 22 validated variants. Select genotypes and watch the percentile animate in real time.
The sequencing pipeline.
One sequencing run.
A lifetime of genomic insight.
WES at $349. WGS at $599. Every kit includes Pharmacogenomics, Skin Genomics, and Genetic Wellness reports — plus raw data that powers every future panel we release.